Synthesis and Characterization of Mesoporous Silica MCM-41 and its use as Potential Drug Carrier
Keywords:
Mesoporous Silica, Potential Drug Carrier, Scanning Electron MicroscopyAbstract
In developing countries to control viral and microbial infections, it is one of the biggest challenges to develop a resistance against antiviral and anti-microbial. This study was aimed at drug-loaded mesoporous silica nanoparticles (MSN)” with ciprofloxacin and daclatasvir. Drug- loaded mesoporous silica nanoparticles were prepared & studied their releasing properties. The prepared materials were characterized by “Fourier- transform infrared spectroscopy” (FTIR), “nitrogen adsorption/desorption analysis, and “scanning electron microscopy”” (SEM). Nanoparticles were loaded with drugs ciprofloxacin and daclatasvir for 24 hours which shows percent loading as 38.7% and 45.5% respectively. The results show that separate and distinct profiles were observed for both drugs. The MCM-41 loaded with Daclatasvir shows a faster rate of drug release compared to MCM-41 loaded with Ciprofloxacin. The finding suggests that MCM -41 could be a potential drug carrier system for controlled and extended release of antiviral and microbial drugs to enhance the drug efficiency to heal and treat infectious diseases. The release profile of both drugs was studied for 24 hours in vitro drug release.
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